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Stacey S. Huppert, Ph.D.

Huppert Assistant Professor of Cell and Developmental Biology
VICC Member

Dr. Huppert graduated from Purdue University completing a Genetic Biology Honors Thesis from the Department of Biology in 1992. She received her Ph.D. degree in Genetics from Indiana University Department of Biology in 1998. After her post-doctoral training with Dr. Raphael Kopan at Washington University School of Medicine in the Department of Molecular Biology and Pharmacology, Stacey joined the Vanderbilt faculty as the first recruit for the Vanderbilt Center for Stem Cell Biology in October of 2005. In August 2012, Stacey moved her research program to Cincinnati Children’s Hospital Medical Center.

Dr. Huppert’s research program explores how intercellular signaling pathways are integrated in both developmental and disease responses of the liver and the lung. Notch signaling is a specific focus of the Huppert laboratory, and one pathway that holds promise as a therapeutic target for treatment of many cancers and diseases. It is the goal of Dr. Huppert’s group to identify novel therapeutics that will specifically target Notch signaling. Combining cellular and biochemical assays with their advanced methods to quantify three-dimensional changes in vascular and epithelial structures will enable the lab to search for targets that fine-tune regulation of the Notch pathway. Dr. Huppert’s research has been published in the following journals: Nature, Developmental Cell, Science Signaling, Hepatology, Disease Models & Mechanisms, and Development.